This policy note outlines South Africa's economic growth and development agenda, presenting a harmonized approach for investing in human capital. Using a life cycle approach, it emphasizes holistic, cross-sectoral investment in early childhood, school age, and youth to adulthood. The analysis identifies priority challenges and proposes an action framework. It aims to foster dialogue among government entities, including Health, Basic Education, Higher Education, Social Development, National Treasury, Planning, and the Presidency, and to inform civil society, development partners, and the private sector about human capital development challenges and coordination needs. The note also encourages further research to address information gaps.